Optogenetic regulation of endogenous proteins.

The results indicated an immediate reduction in the ability of cells to move the edge efficiently (both in protrusion and in retraction) after switching on 740 nm light (600–2400 s), which reached a maximum and highly significant attenuation ( p < 0.01 (two tailed, Student’s t test)) by 1800–2400 s (Fig. 5f, g ).

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