Tumor suppressor genes and allele-specific expression: mechanisms and significance.

Oncotarget · 2020 · PMC6996918 · PMID 32064050

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may be significantno p-value reported

However, if recessive LOF alleles can be significantly overexpressed relative to the wild-type alleles in an ASE fashion, LOF TSGs may be significant contributors to cancer onset/progression even in the heterozygous state.

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