Celebrating 20 Years of IGHV Mutation Analysis in CLL.

Hemasphere · 2020 · PMC7000474 · PMID 32382709

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http://creativecommons.org/licenses/by-nd/4.0 Abstract The division of CLL into 2 broad subsets with highly significant differences in clinical behavior was reported in 2 landmark papers in Blood in 1999. 1 , 2 The simple analysis of the mutational status of the IGV regions provided both a prognostic indicator and an insight into the cellular origins.

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