Time to relapse: It is defined from completion of first line treatment and is the most important prognostic factor at the point of relapse and highly significant for OS and EFS in pediatric studies dominating all other prognostic factors in multivariate analysis of the ST-HD-86 study (p 0.0001) for example.
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Risk and Response Adapted Treatment Guidelines for Managing First Relapsed and Refractory Classical Hodgkin Lymphoma in Children and Young People. Recommendations from the EuroNet Pediatric Hodgkin Lymphoma Group.
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