Whole-genome comparison between the type strain of Halobacterium salinarum (DSM 3754^T ) and the laboratory strains R1 and NRC-1.

Overall structure of the replicons For the chromosome, a cumulative GC‐skew plot (Figure 1 , inner‐most ring) shows an overall trend of increasing GC‐skew while moving clockwise from the top, around the circle, and back to the top, with a strong inflection near the canonical replication origin (point of ring opening).

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Regarding the relative rate of divergence, it may be significant that the NCBI taxonomy lists only six species of Halobacterium ( https://www.ncbi.nlm.nih.gov/Taxonomy ) despite its ease of cultivation and decades of isolation studies, while more recently discovered genera with similar cultivability have far more described species ( Halorubrum , 46; Haloferax , 19; Haloarcula , 16), with new species reported frequently ( http://www.bacterio.net/halorubrum.html ).

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