Seronegative hepatitis C virus infection in Polish blood donors-Virological characteristics of index donations and follow-up observations.

2 Despite a decreasing trend, the HCV NAT‐only detection rate remains high in Poland with the residual risk of transfusion‐transmitted infection. 3 , 4 One recently published study aiming to explain the high rate of HCV WP donations in Poland pointed to the likely impact of questionnaire design and donor compliance. 5 The objective of the current study was to analyze the frequency of HCV NAT yields in Poland in the years 2000 to 2016 and to provide virological characterization of index donations and follow‐up samples.

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In an analysis encompassing years 2005 to 2015, the relative risk for first time versus repeat blood donors was over 25 and highly significant. 10 These observations may suggest that at least part of seronegative HCV RNA positive donations come from repeat donors who give blood to learn about their infection status.

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