A retrospective matched-cohort study of 3994 lower extremity wounds of multiple etiologies across 644 institutions comparing a bioactive human skin allograft, TheraSkin, plus standard of care, to standard of care alone.

21 , 22 , 23 Meta‐analyses, in which data from numerous studies are combined to create a very large pool of data, do not solve the problems created by RCT's because they typically draw from RCT's for data, and there may be significant variations in the treatment protocols from study to study that may further confound the results.

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