De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.

Proc Natl Acad Sci U S A · 2020 · PMC7007577 · PMID 31964835

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highly significantP < 2.98 × 10 −162actually significant

As expected based on previous studies ( 8 , 19 ), we found a highly significant association between DNM rate per individual and paternal age (linear regression, R 2 = 0.410, P < 2.98 × 10 −162 ) ( SI Appendix , Fig.

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