Optimization of Extraction Conditions of Phytochemical Compounds and Anti-Gout Activity of <i>Euphorbia hirta</i> L. (Ara Tanah) Using Response Surface Methodology and Liquid Chromatography-Mass Spectrometry (LC-MS) Analysis.

For the responses of TFC, TPC, and XO inhibitory activity, the models were highly significant when the computed F -values were greater than the tabulated F -value and the probability values were low ( p < 0.001), indicating that the individual terms in each response model were significant on the interaction effect.

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