Pain management protocol implementation and opioid consumption in critical care: an interrupted time series analysis.

In the segmented regression analysis by ICU patient-days, fentanyl presented with an increasing trend in use before the intervention (β = 16; 95%CI 7 - 25; p = 0.002), which decreased in level (β = - 128; 95%CI -195 - -62; p = 0.001) and then in slope for a decreasing trend (β = - 24; 95%CI -35 - -13; p < 0.001) ( Table 2 , Figure 2 ).

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There was an increasing trend in the utilization of dipyrone.

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