Therefore, use of the viral non-structural protein NS1 secreted by Flaviviruses, a family of highly significant vector borne viruses that include that infectious cause of Zika, Dengue, west Nile fever and Tick-borne encephalitis, has been proposed as a more specific antigen for detecting specific immune responses.
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Comparative specificity and sensitivity of NS1-based serological assays for the detection of flavivirus immune response.
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