Although there was no significant association between the COL3A1 SNP and POP, there was a trend toward significance for COL14A1 SNP (rs2305603), COL4A2 SNP (rs74941798), two COL1A1 SNPs (rs2586488 and rs2249492) and three COL18A1 SNPs (rs1050351, rs56335679, and rs55690336), and POP.
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Genetic polymorphisms in collagen-related genes are associated with pelvic organ prolapse.
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P values less than 0.05 were considered to be significant and less than 0.1 to be borderline significant.