Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells.

Notably, there was a highly significant overlap of senescence-associated metabolic changes in MSCs and iMSCs: 67 metabolites were consistently downregulated (hypergeometric distribution: p < 10 −43 ) and 9 metabolites were upregulated at later passages in both cell types (p < 10 −10 ; Figure 3 C).

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