Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects.

Int J Mol Sci · 2020 · PMC7013458 · PMID 31941101

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Analysis of the DNA methylation at the VEGFA locus revealed a strong and highly significant reduction of the off-target DNA methylation introduced by the mutants in comparison to the wild type ( Figure 3 B).

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