How nasopharyngeal pneumococcal carriage evolved during and after a PCV13-to-PCV10 vaccination programme switch in Belgium, 2016 to 2018.

Euro Surveill · 2020 · PMC7014673 · PMID 32046817

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a decreasing trendp < 0.001actually significant

Nevertheless, a decreasing trend (p < 0.001) was observed for history of acute otitis media (AOM-history) and AB-use in the 3 months before sampling.

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an increasing trendp < 0.001actually significant

Trends over time in carriage prevalence of Streptococcus pneumoniae serotypes Among the Sp-carriers based on Quellung-results, a decreasing trend (p < 0.001) in the proportion of non-PCV13-VTs (94.6%, 438/463 isolates in 2016 vs 96.9%, 594/613 isolates in 2016–2017 vs 89.7%, 599/668 isolates in 2017–2018) was accompanied by an increasing trend (p < 0.001) in the proportion of PCV13-non-PCV10-VTs (3 + 6A + 19A: 0.9%, 4/463 isolates in 2016 vs 1.6%, 10/613 isolates in 2016–2017 vs 7.8%, 52/668 isolates in 2017–2018; Figure 1 ).

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