Study of Melatonin as Preventive Agent of Gastrointestinal Damage Induced by Sodium Diclofenac.

Cells · 2020 · PMC7016873 · PMID 31936877

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extremely significantno p-value reported

p value from 0.01 to 0.05, 0.01 to 0.001, and p < 0.001 were considered statistically significant, very significant and extremely significant, respectively.

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highly significantno p-value reported

To evaluate the role of MLT in GI injury prevention induced by NSAIDs, SD was selected as GI damage model because this NSAID has a pKa of 4.15 [ 52 ] and as explained before, there is a highly significant inverse correlation between pKa and concentration required for maximum stimulation of mitochondrial oxidative stress.

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