CD163⁺ tumor-associated macrophage accumulation in breast cancer patients reflects both local differentiation signals and systemic skewing of monocytes.

This sensitive signature score was also more significantly enriched in monocytes expressing a high OXPHOS score, compared to the refractory signature score, which was at the limit of significance when comparing monocytes with high versus low OXPHOS status in the Cassetta cohort ( P = 0.045; Figure 6 f).

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