Stem Cell-Induced Inflammation in Cholesteatoma is Inhibited by the TLR4 Antagonist LPS-RS.

Cells · 2020 · PMC7017370 · PMID 31947538

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Treatment of ME-CSCs from three independent donors with LPS resulted in a strong and highly significant upregulation of pro-inflammatory mediators IL- 1α, IL-1ß, IL-6, and IL-8 in comparison to untreated control ( Figure 2 C and Figure S2 ).

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