Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination.

However, the F1076L mutation in the longitudinal samples from the China–Myanmar border had an increasing trend in prevalence; its frequency reached 77.8% in 2015, almost doubled from that (41.7%) in 2012–2013.

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Similarly, the Y976F prevalence also showed a decreasing trend in the Thailand–Myanmar and Thailand–Cambodia border samples collected in 2008 and 2014 [ 33 , 62 ].

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