Barely Significant
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Nickel-catalyzed C-H alkylation of indoles with unactivated alkyl chlorides: evidence of a Ni(i)/Ni(iii) pathway.

Chem Sci · 2019 · PMC7017866 · PMID 32110305

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highly significantno p-value reported
The coupling of C(sp 3 )–Br and C(sp 3 )–I sites in the presence of a C(sp 3 )–Cl bond and selective one C(sp 3 )–Cl coupling (in the case of 1,6-dichlorohexane) are highly significant, as the resulting products can be used for further functionalization.

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