a trend toward significancep = 0.08
There was a trend toward significance between C1 and C2 patients [Hazard for C1/C2: p = 0.08, HR: 0.51 (95%CI, 0.25–1.04)], while C3 patients had a significantly lower mOS compared to C2 [Hazard for C2/C3: p = 0.013, HR: 0.39 (95%CI, 0.14–1.09)] and obviously C1 [Hazard for C1/C3: p < 0.001, HR: 0.21 (95%CI, 0.06–0.70)] ( Figure 3B ).