Pathological Roles of Mitochondrial Oxidative Stress and Mitochondrial Dynamics in Cardiac Microvascular Ischemia/Reperfusion Injury.

Of note, NOX4 is localized along the inner mitochondrial membrane, and the potential interaction between these two sources of ROS may be significant determinants of the total mtROS in the endothelium [ 67 , 68 ].

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