highly significantp < 0.001
THQ-loaded-PLGA-NPs observed the highly significant value by intranasal (***p < 0.001), THQ-loaded-PLGA-NPs (IV) (**p < 0.01), THQ-S (IN) (*p < 0.05), when all compared with pure THQ (IV) solution.
THQ-loaded-PLGA-NPs observed the highly significant value by intranasal (***p < 0.001), THQ-loaded-PLGA-NPs (IV) (**p < 0.01), THQ-S (IN) (*p < 0.05), when all compared with pure THQ (IV) solution.