Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child.

Transl Psychiatry · 2020 · PMC7026113 · PMID 32066722

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0800

boldest claim

The sentences

marginal significanceP = 0.058so close (0.05 < p ≤ 0.1)

After this procedure, a marginal significance of the right hippocampus was found ( P = 0.058, SVC corrected).

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a slight trendP = 0.08so close (0.05 < p ≤ 0.1)

In contrast, for the region of bilateral putamen, the DC was weaker in COMT Met- BDNF Val/Val than in COMT Met- BDNF Met subgroups, but higher in COMT Val/Val- BDNF Val/Val than in COMT Val/Val- BDNF Met subgroups (in the left putamen, there was no significant difference but a slight trend of COMT Met- BDNF Val/Val < COMT Met- BDNF Met, with P = 0.08).

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just marginally significantno p-value reported

As the hippocampus here was just marginally significant after multiple testing corrections, we explain the underlying biological mechanisms with caution.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.