Barely Significant
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The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Lancet Gastroenterol Hepatol · 2020 · PMC7026710 · PMID 31981519

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a decreasing trendno p-value reported
However, unlike high-income North America, these regions, with the exception of eastern Europe, all experienced a decreasing trend in death rates in the middle-aged age groups over the study period.

also in 47,180 other papers

an increasing trendno p-value reported
In high-income North America in 2017, the number of deaths was highest in the age groups from 50 to 69 years for both sexes combined, with an increasing trend in both the number and rate of deaths in these age groups from 1990 to 2017.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.