Pulsed radiofrequency alleviated neuropathic pain by down-regulating the expression of substance P in chronic constriction injury rat model.

At 14 and 28 days after PRF treatment, the HWT values of the C-P group showed highly significant differences from the HWT values of the C-S group (95% CI: 0.28–17.62; P < 0.01, 95% CI: 5.84–19.50; P < 0.01) and no significant differences from the HWT values of the S-S group (95% CI: −1.82 to 9.52; P = 0.364, 95% CI: −2.92–6.82; P = 0.413) [Figure 1 ].

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