It would be extremely significant from a disease modelling standpoint to assess whether or not TTBK2 conditional mice exhibit similar pathological tau accumulation outside the cerebellum vis-à-vis SCA11. 4) The main concern is that the analyses are based exclusively on the general architecture of the cerebellum.
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TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.
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