Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory.

I agree with the authors that the isoform diversity of microtubule motors in neurons is understudied and important for the understanding of neuronal function, and this work is potentially highly significant in demonstrating some aspects of this and I support its publication.

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Wild-type mice showed a learning progress during the acquisition phase as indicated by a decreasing trend of primary errors they made during training, but such learning progress was not observed in homozygous mice.

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