Fecal Metabolomic Signatures in Colorectal Adenoma Patients Are Associated with Gut Microbiota and Early Events of Colorectal Cancer Pathogenesis.

While the presence of adenoma or carcinoma did not seem to affect the correlation between microbial PCo1 and metabolite PC1, females showed a higher microbial PCo1-metabolite PC1 correlation than males (Spearman’s ρ = −0.772, P < 10 −19 for females; Spearman’s ρ = −0.643, P < 10 −17 for males; difference was marginally significant when tested using Fisher r -to- z transformation, P < 0.06).

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