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Disease characteristics and treatment patterns of Chinese patients with metastatic colorectal cancer: a retrospective study using medical records from China.

BMC Cancer · 2020 · PMC7029588 · PMID 32070312

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an increasing trendno p-value reported
There was an increasing trend of using targeted biologics in third-line therapy.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.