marginally significantp < 0.005
To identify signaling pathways impacted by differentially expressed genes in Cort Cre ;TrkB flox/flox cortex compared with control, we performed gene ontology (GO) analysis on the subset of 269 marginally significant (at p < 0.005) genes with Entrez gene IDs, stratified by directionality (133 more highly expressed in control and 136 more highly expressed in Cort Cre ;TrkB flox/flox ; Fig. 1 C , Extended Data Fig. 1-2 ).