Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.

As expected, there was significant enrichment of pathways involved in ‘bacterial invasion of epithelial cells’, ‘tight junctions’, ‘cytokine-cytokine receptor interactions’ and ‘colorectal cancer’; however, we also observed a highly significant association with ‘apoptosis’ (p<10 −7 ) ( online supplementary figure 6 ).

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