Investigation of the Correlation between Androgen Receptor and ZEB1 and its Value in Progression of Gastric Cancer.

Androgen receptor Enzalutamide Gastric cancer Prognostic marker Targeted therapy ZEB1 pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement no pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY Introduction Although the incidence of Gastric Cancer (GC) shows a decreasing trend in the last decade, most GC patients are initially diagnosed at late TNM (Tumor, Node, Metastasis) stages or with distant metastases who have poor prognosis 1 .

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Moreover, ZEB1 overexpression was marginally significant when GC tumor size is concerned. 31 patients out of 40 cases who had tumor bigger than 5 cm , overexpressed ZEB1 gene (77.5%).

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