Comparison of compound 1 and the similar flavonoids 2 and 3 suggests that the replacement of the C-5 methoxy group with a hydroxyl group may be significant.
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Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species.
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It is important to note however, the results of the modulation assays simply indicate a possible trend towards efflux inhibition rather than a precise prediction [ 41 , 42 ].