Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation.

We quantified the number of muscle fibers with central nuclei in cross sections of the RA, and found a quasi-significant difference by comparing controls and C26 cachectic mice ( p = 0.09; Figure 3 B).

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Worth noting, the experiments in mice last a few weeks only, while humans are analyzed several weeks following the tumor onset, and indeed the phenomenon in humans is one order of magnitude bigger (about 20% of fibers with central nuclei in cachectic patients) and, therefore, definitely significant from a pathophysiological point of view.

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