highly significantP < 2.2 × 10 −16
Similarly, the differences in length and Alu count of the downstream intron between the predominant A5BS circRNAs and the other A5BS circRNAs were highly significant ( P < 2.2 × 10 −16 ; Figure 4E , F ) while they were much less or not significant for the upstream flanking introns of A3BS circRNAs ( Supplementary Figure S5C, D ).