Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.

Cell Rep · 2020 · PMC7039685 · PMID 32049011

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highly significantno p-value reported

Although this may appear a small effect, it represents an approximately 19% increase in mitochondrial respiration dedicated to making ATP, which, in bioenergetic terms, is highly significant.

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