Quantification of fluorophore distribution and therapeutic response in matched in vivo and ex vivo pancreatic cancer model systems.

In vitro competitive binding studies comparing the parent drug with labeled gemcitabine showed a decreasing trend in fluorescence intensity with increased unlabeled gemcitabine concentration co-incubation in the gemcitabine sensitive PANC-1 cell lines, although variability was high ( S3 Fig ).

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