IGFBP7 acts as a negative regulator of RANKL-induced osteoclastogenesis and oestrogen deficiency-induced bone loss.

As is shown in Figure S5 , although no statistical significance between groups was reached, there was an obvious trend that more TRAP‐positive cells were formed in the co‐culture system containing MC3T3‐E1 cells with IGFBP7 knockdown, when compared with the control group.

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