School performance in children born after ICSI.

Hum Reprod · 2020 · PMC7048711 · PMID 31957795

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borderline significantno p-value reported

A large registry study from Sweden ( Sandin et al ., 2013 ) found no overall risk of mental retardation or autistic disorders in ART singletons compared to spontaneously conceived singletons in the main analysis, but a small increase in mental retardation in a subanalysis of ICSI singletons, compared to IVF, being borderline significant for fresh ICSI and significant for frozen ICSI.

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an increasing trendno p-value reported

In recent years, there has been an increasing trend towards using ICSI not only for treatment of male infertility but also when the sperm quality is normal.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.