In vitro ribosome synthesis and evolution through ribosome display.

Finally, we observed a highly significant increase (one-sided Student’s t -test, p = 2.2 × 10 −16 ) in average epistasis values in the winning CR genotypes compared with the overall population, indicating that positive epistasis plays an important role in determining the fittest genotypes in this selection (Fig. 5b ).

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Deep sequencing analysis from the clindamycin selection reveals a densely connected network of winning genotypes, which display an overall trend of positive epistasis, suggesting the importance of epistatic interactions in evolving ribosome function.

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