When CGP 54626 was administered after 2 days of ethanol tolerance, the ST50 values were increased to highly significant values when compared with the control for day 3 at all the CGP 54246 concentrations used, before slowly losing efficacy on day 4 (2 days/48 hours after initial administration) and there being an evident decrease in significance when compared with the control for day 4 in a dose dependent manner (Figure 7 C,D). 4.
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Pharmacological targeting of the GABA<sub>B</sub> receptor alters Drosophila's behavioural responses to alcohol.
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