Association of intrathecal pleocytosis and IgG synthesis with axonal damage in early MS.

sNfL level increase is associated with cerebral and spinal relapse manifestation sNfL levels tended to be higher during clinical relapse (n = 79, median 9.91 pg/mL, IQR 6.05–17.77 pg/mL) in comparison to samples taken from clinically stable patients (n = 33, median 8.43 pg/mL, IQR 5.41–11.51 pg/mL), but the difference failed to reach significance ( p = 0.095).

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sNfL level increase is associated with T2 lesion load and the presence of CELs in MRI We found a highly significant increase in sNfL levels in the presence of CELs in MRI (patients with CELs: n = 50, median 10.98 pg/mL, IQR 7.67–26.11 pg/mL; patients without CELs: n = 62, median 7.78 pg/mL, IQR 5.54–11.90 pg/mL, p = 0.001) ( figure 2A ).

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