10 , 11 , 12 There is an overall trend of microglial hyperreactivity in aged mice. 13 , 14 In humans, dystrophy and degeneration of microglia, which result in deterioration of the defensive and neuroprotective capabilities of the senescent CNS, are implicated in brain aging. 15 In turn, aging is related to low‐grade neuroinflammation, i
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