<i>PIK3CA</i> gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies.

Kaplan-Merier (KM) curves after PSM still showed a marginally significant difference between PIK3CA -HD mutant and PIK3CA -KD mutant MBCs ( Supplementary Figure 1 , Logrank p=0.13), suggesting PIK3CA -HD mutation itself to be an important risk factor for poor prognosis for MBCs in late-line therapy.

also in 26,082 other papers

All tests of hypotheses were two-tailed and conducted at a significance level of 0.05 and at a marginal significance level of 0.15.

also in 5,069 other papers