Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs.

Sci Adv · 2020 · PMC7056305 · PMID 32181354

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

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boldest claim

The sentences

did not quite reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)

The differences between the construct with zero additional gRNA elements and the others were statistically significant ( P < 0.0001 in both cases, Fisher’s exact test), although the difference between the constructs with one and four additional gRNAs did not quite reach statistical significance ( P = 0.06, Fisher’s exact test).

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