Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations.

For each data set, we examined whether scaled connectivity (a metric of whether a gene is acting as a “hub”) correlated with the depth of literature base using Kendall rank correlation; in the PRAD dataset, the correlation was miniscule, negative, and barely statistically significant; in the COAD data set, the correlation was miniscule, positive, and statistically significant, and the correlation was insignificant in the GBMLGG dataset (Fig. 2a–c ).

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