The strengths of the study include: comprehensive evaluation of transcriptional (qPCR, RNA-seq), chromatin (ATAC-seq), and functional (self-renewal, and bipotent differentiation) readouts of the trophoblast stem cell phenotype, systematic comparison of trophoblast differentiation potential between naive and primed pluripotency starting cell states, clear and convincing presentation, and highly significant work.
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Derivation of trophoblast stem cells from naïve human pluripotent stem cells.
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