Barely Significant
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Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks.

Cells · 2020 · PMC7072483 · PMID 32024090

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highly significantno p-value reported
Consequently, a highly significant imbalance of the sphingolipid rheostat occurs, shifting the S1P/ceramide ratio toward S1P by about 20-fold.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.