Genetic background modifies phenotypic severity and longevity in a mouse model of Niemann-Pick disease type C1.

Dis Model Mech · 2020 · PMC7075069 · PMID 31996359

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highly significantno p-value reported

However, the number of Npc1 em/em mutants from the N2 generation in this study ( n =202) was large enough to reveal two QTLs with highly significant LOD scores, suggesting a sufficient sample size was used for analysis of this NPC1 phenotype.

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